During the 2009 H1N1 pandemic, InFACT led a global collaboration to collect data on the  epidemiology of severe H1N1 influenza, and to launch collaborative clinical trials of plausibly effective and inexpensive interventions. This initiative linked five databases from member research groups, and resulted in the collection of data on in excess of 5000 critically ill patients with H1N1 influenza.

InFACT has joined the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) to collaborate in a broad international response to the challenge of future pandemics and emerging infections. We have a seat on the ISARIC executive committee, and lead several of the ISARIC working groups. Currently, InFACT is part of the SPRINT-SARI research consortium to standardize inter-pandemic data collection for severe acute respiratory infection. SPRINT-SARI (Short Period Incidence Study of Severe Acute Respiratory Infection) is an international, multi-centre prospective short-period observational study to establish research infrastructure in the inter-pandemic period and to better describe the descriptive epidemiology and microbiology profiles of sick patients with severe acute respiratory infections.